CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1190.20
Functional Family Ketohexokinase

Enzyme Information

2.7.1.3
Ketohexokinase.
based on mapping to UniProt P50053
ATP + D-fructose = ADP + D-fructose 1-phosphate.
-!- D-sorbose, D-agatose and 5-dehydro-D-fructose also act as acceptors.

UniProtKB Entries (1)

P50053
KHK_HUMAN
Homo sapiens
Ketohexokinase

PDB Structure

PDB 5WBP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
Huard, K., Ahn, K., Amor, P., Beebe, D.A., Borzilleri, K.A., Chrunyk, B.A., Coffey, S.B., Cong, Y., Conn, E.L., Culp, J.S., Dowling, M.S., Gorgoglione, M.F., Gutierrez, J.A., Knafels, J.D., Lachapelle, E.A., Pandit, J., Parris, K.D., Perez, S., Pfefferkorn, J.A., Price, D.A., Raymer, B., Ross, T.T., Shavnya, A., Smith, A.C., Subashi, T.A., Tesz, G.J., Thuma, B.A., Tu, M., Weaver, J.D., Weng, Y., Withka, J.M., Xing, G., Magee, T.V.
J. Med. Chem.