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1 keywords

CATH Domain 5w8fA01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.437 Apoptosis Regulator Bcl-x
Homologous Superfamily 1.10.437.10 Blc2-like

Domain Context

CATH Clusters

Superfamily Blc2-like
Functional Family Induced myeloid leukemia cell differentiation protein Mcl-1

Enzyme Information

UniProtKB Entries (1)

Q07820
MCL1_HUMAN
Homo sapiens
Induced myeloid leukemia cell differentiation protein Mcl-1

PDB Structure

PDB 5W8F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Rezaei Araghi, R., Bird, G.H., Ryan, J.A., Jenson, J.M., Godes, M., Pritz, J.R., Grant, R.A., Letai, A., Walensky, L.D., Keating, A.E.
Proc. Natl. Acad. Sci. U.S.A.
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