1 keywords

CATH Domain 5w18D00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.226 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous Superfamily 3.90.226.10 2-enoyl-CoA Hydratase; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt Q2G036
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

Q2G036
CLPP_STAA8
Staphylococcus aureus subsp. aureus NCTC 8325
ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB 5W18
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ureadepsipeptides as ClpP Activators.
Griffith, E.C., Zhao, Y., Singh, A.P., Conlon, B.P., Tangallapally, R., Shadrick, W.R., Liu, J., Wallace, M.J., Yang, L., Elmore, J.M., Li, Y., Zheng, Z., Miller, D.J., Cheramie, M.N., Lee, R.B., LaFleur, M.D., Lewis, K., Lee, R.E.
Acs Infect Dis.