CATH Domain 5vqnA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.91	Restriction Endonuclease
	3.40.91.90	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain

Domain Context

CATH Clusters

Superfamily	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

C3W5S0_I09A0

Influenza A virus (A/California/04/2009(H1N1))

Polymerase acidic protein

PDB Structure

PDB	5VQN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors. Jones, J.C., Kumar, G., Barman, S., Najera, I., White, S.W., Webby, R.J., Govorkova, E.A. MBio