CATH Domain 5vfdA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q8RLA6_ACIBA

Acinetobacter baumannii

Beta-lactamase

PDB Structure

PDB	5VFD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	ETX2514 is a broad-spectrum beta-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Durand-Reville, T.F., Guler, S., Comita-Prevoir, J., Chen, B., Bifulco, N., Huynh, H., Lahiri, S., Shapiro, A.B., McLeod, S.M., Carter, N.M., Moussa, S.H., Velez-Vega, C., Olivier, N.B., McLaughlin, R., Gao, N., Thresher, J., Palmer, T., Andrews, B., Giacobbe, R.A., Newman, J.V., Ehmann, D.E., de Jonge, B., O'Donnell, J., Mueller, J.P., Tommasi, R.A., Miller, A.A. Nat Microbiol