CATH Domain 5v3oC01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.150	Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
	2.170.150.20	Peptide methionine sulfoxide reductase.

Domain Context

CATH Clusters

Superfamily	Peptide methionine sulfoxide reductase.
Functional Family	Cereblon, isoform CRA_c

Enzyme Information

UniProtKB Entries (1)

CRBN_HUMAN

Homo sapiens

Protein cereblon

PDB Structure

PDB	5V3O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. Matyskiela, M.E., Zhang, W., Man, H.W., Muller, G., Khambatta, G., Baculi, F., Hickman, M., LeBrun, L., Pagarigan, B., Carmel, G., Lu, C.C., Lu, G., Riley, M., Satoh, Y., Schafer, P., Daniel, T.O., Carmichael, J., Cathers, B.E., Chamberlain, P.P. J. Med. Chem.