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1 keywords

CATH Domain 5uulA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.437 Apoptosis Regulator Bcl-x
Homologous Superfamily 1.10.437.10 Blc2-like

Domain Context

CATH Clusters

Superfamily Blc2-like
Functional Family Bcl-2-related protein A1

Enzyme Information

UniProtKB Entries (1)

Q16548
B2LA1_HUMAN
Homo sapiens
Bcl-2-related protein A1

PDB Structure

PDB 5UUL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Jenson, J.M., Ryan, J.A., Grant, R.A., Letai, A., Keating, A.E.
Elife
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