1 keywords

CATH Domain 5um9A01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.1010 5'-nuclease

Domain Context

CATH Clusters

Superfamily 5'-nuclease
Functional Family Flap endonuclease 1

Enzyme Information

3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P39748

UniProtKB Entries (1)

P39748
FEN1_HUMAN
Homo sapiens
Flap endonuclease 1

PDB Structure

PDB 5UM9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Tsutakawa, S.E., Thompson, M.J., Arvai, A.S., Neil, A.J., Shaw, S.J., Algasaier, S.I., Kim, J.C., Finger, L.D., Jardine, E., Gotham, V.J.B., Sarker, A.H., Her, M.Z., Rashid, F., Hamdan, S.M., Mirkin, S.M., Grasby, J.A., Tainer, J.A.
Nat Commun