CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt Q9F663
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

Q9F663
BLKPC_KLEPN
Klebsiella pneumoniae
Carbapenem-hydrolyzing beta-lactamase KPC

PDB Structure

PDB 5UJ3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).
Pemberton, O.A., Zhang, X., Chen, Y.
J. Med. Chem.