CATH Classification
Domain Context
CATH Clusters
| Superfamily | 3.30.1130.10 |
| Functional Family |
Enzyme Information
| 1.7.1.13 |
PreQ(1) synthase.
based on mapping to UniProt O31678
7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-carbaguanine + 2 NADPH.
-!- The reaction occurs in the reverse direction. -!- This enzyme catalyzes one of the early steps in the synthesis of queosine (Q-tRNA), and is followed by the action of EC 2.4.2.29. -!- Queosine is found in the wobble position of tRNA(GUN) in eukaryotes and bacteria and is thought to be involved in translational modulation.
|
UniProtKB Entries (1)
| O31678 |
QUEF_BACSU
Bacillus subtilis subsp. subtilis str. 168
NADPH-dependent 7-cyano-7-deazaguanine reductase
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PDB Structure
| PDB | 5UDG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide.
Biomolecules
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