CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.47 | Peroxisomal Thiolase; Chain A, domain 1 |
|
3.40.47.10 | Thiolase/Chalcone synthase |
Domain Context
CATH Clusters
| Superfamily | 3.40.47.10 |
| Functional Family | Chalcone synthase 1 |
Enzyme Information
| 2.3.1.151 |
2,3',4,6-tetrahydroxybenzophenone synthase.
based on mapping to UniProt Q8SAS8
3 malonyl-CoA + 3-hydroxybenzoyl-CoA = 4 CoA + 2,3',4,6- tetrahydroxybenzophenone + 3 CO(2).
-!- Involved in the biosynthesis of plant xanthones. -!- Benzoyl-CoA can replace 3-hydroxybenzoyl-CoA (cf. EC 2.3.1.220).
|
| 2.3.1.220 |
2,4,6-trihydroxybenzophenone synthase.
based on mapping to UniProt Q8SAS8
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO(2).
-!- Involved in the biosynthesis of plant xanthones. -!- The enzyme from the plant Hypericum androsaemum L can use 3-hydroxybenzoyl-CoA instead of benzoyl-CoA, but with lower activity (cf. EC 2.3.1.151).
|
UniProtKB Entries (1)
| Q8SAS8 |
TBSYN_HYPAN
Hypericum androsaemum
2,4,6-trihydroxybenzophenone synthase
|
PDB Structure
| PDB | 5UCO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular architectures of benzoic acid-specific type III polyketide synthases.
Acta Crystallogr D Struct Biol
|
