CATH Classification

Domain Context

CATH Clusters

Superfamily YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family Polycomb protein eed

Enzyme Information

UniProtKB Entries (1)

Q15910
EZH2_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase EZH2

PDB Structure

PDB 5U62
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Lingel, A., Sendzik, M., Huang, Y., Shultz, M.D., Cantwell, J., Dillon, M.P., Fu, X., Fuller, J., Gabriel, T., Gu, J., Jiang, X., Li, L., Liang, F., McKenna, M., Qi, W., Rao, W., Sheng, X., Shu, W., Sutton, J., Taft, B., Wang, L., Zeng, J., Zhang, H., Zhang, M., Zhao, K., Lindvall, M., Bussiere, D.E.
J. Med. Chem.