1 keywords

CATH Domain 5tr4C01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.50 3-Layer(bba) Sandwich
Topology 3.50.50 FAD/NAD(P)-binding domain
Homologous Superfamily 3.50.50.80 Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1

Domain Context

CATH Clusters

Superfamily Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1
Functional Family ubiquitin-like modifier-activating enzyme 1

Enzyme Information

UniProtKB Entries (0)

PDB Structure

PDB 5TR4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification and Characterization of a Small Molecule Inhibitor of the Ubiquitin Activating Enzyme (TAK-243)
Hyer, M., Milhollen, M., Ciavarri, J., Fleming, P., Traore, T., Sappal, D., Huck, J., Shi, J., Gavin, J., Brownell, J., Yang, Y., Stringer, B., Griffin, R., Bruzzese, F., Soucy, T., Duffy, J., Rabino, C., Riceberg, J., Hoar, K., Lublinsky, A., Menon, S., Sintchak, M., Bump, N., Pulukuri, S., Amidon, B., Langston, S., Tirrell, S., Kuranda, M., Veiby, P., Newcomb, J., Li, P., Wu, J., Dick, L., Greenspan, P., Galvin, K., Manfredi, M., Claibrone, C., Bence, N.
To be published