CATH Classification

Domain Context

CATH Clusters

Superfamily Lipoxygenase-1; Domain 2
Functional Family

Enzyme Information

1.13.11.12
Linoleate 13S-lipoxygenase.
based on mapping to UniProt P08170
(1) Linoleate + O(2) = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate. (2) Alpha-linolenate + O(2) = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca- 9,11,15-trienoate.
-!- A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(13) position with (S)- configuration. -!- This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. -!- EC 1.13.11.58 catalyzes a similar reaction at the second available position of these fatty acids. -!- Formerly EC 1.13.1.13 and EC 1.99.2.1.

UniProtKB Entries (1)

P08170
LOX1_SOYBN
Glycine max
Seed linoleate 13S-lipoxygenase-1

PDB Structure

PDB 5TQO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.
Hu, S., Offenbacher, A.R., Thompson, E.M., Gee, C.L., Wilcoxen, J., Carr, C.A.M., Prigozhin, D.M., Yang, V., Alber, T., Britt, R.D., Fraser, J.S., Klinman, J.P.
J.Am.Chem.Soc.