CATH Classification

Domain Context

CATH Clusters

Superfamily Isopropylmalate Dehydrogenase
Functional Family Isocitrate dehydrogenase [NADP]

Enzyme Information

1.1.1.42
Isocitrate dehydrogenase (NADP(+)).
based on mapping to UniProt O75874
Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
-!- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NAD(+) but much more slowly.

UniProtKB Entries (1)

O75874
IDHC_HUMAN
Homo sapiens
Isocitrate dehydrogenase [NADP] cytoplasmic

PDB Structure

PDB 5TQH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.
Levell, J.R., Caferro, T., Chenail, G., Dix, I., Dooley, J., Firestone, B., Fortin, P.D., Giraldes, J., Gould, T., Growney, J.D., Jones, M.D., Kulathila, R., Lin, F., Liu, G., Mueller, A., van der Plas, S., Slocum, K., Smith, T., Terranova, R., Toure, B.B., Tyagi, V., Wagner, T., Xie, X., Xu, M., Yang, F.S., Zhou, L.X., Pagliarini, R., Cho, Y.S.
ACS Med Chem Lett