CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Enzyme Information

3.1.4.11
Phosphoinositide phospholipase C.
based on mapping to UniProt P08487
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (2)

P15127
INSR_RAT
Rattus norvegicus
Insulin receptor
P08487
PLCG1_BOVIN
Bos taurus
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

PDB Structure

PDB 5TQ1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein.
McKercher, M.A., Guan, X., Tan, Z., Wuttke, D.S.
Biochemistry