CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.20 | Ubiquitin-like (UB roll) |
|
3.10.20.270 | TmoB-like |
Domain Context
CATH Clusters
| Superfamily | TmoB-like |
| Functional Family |
Enzyme Information
| 1.14.13.236 |
Toluene 4-monooxygenase.
based on mapping to UniProt Q00457
Toluene + NADH + O(2) = 4-methylphenol + NAD(+) + H(2)O.
-!- This bacterial enzyme belongs to a family of soluble diiron hydroxylases that includes toluene-, benzene-, xylene- and methane monooxygenases, phenol hydroxylases, and alkene epoxidases. -!- The enzyme comprises a four-component complex that includes a hydroxylase, NADH-ferredoxin oxidoreductase, a Rieske-type [2Fe-2S] ferredoxin, and an effector protein.
|
UniProtKB Entries (1)
| Q00460 |
TMOE_PSEME
Pseudomonas mendocina
Toluene-4-monooxygenase system, hydroxylase component subunit beta
|
PDB Structure
| PDB | 5TDS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
In-crystal reaction cycle of a toluene-bound diiron hydroxylase.
Nature
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