CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family ectonucleotide pyrophosphatase/phosphodiesterase family member 7

Enzyme Information

3.1.4.12
Sphingomyelin phosphodiesterase.
based on mapping to UniProt Q6UWV6
Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
-!- Has very little activity on phosphatidylcholine.

UniProtKB Entries (1)

Q6UWV6
ENPP7_HUMAN
Homo sapiens
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

PDB Structure

PDB 5TCD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition.
Gorelik, A., Liu, F., Illes, K., Nagar, B.
J. Biol. Chem.