CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.620 | q2cbj1_9rhob like domain |
Domain Context
CATH Clusters
| Superfamily | q2cbj1_9rhob like domain |
| Functional Family | Egl nine homolog 1 |
Enzyme Information
| 1.14.11.29 |
Hypoxia-inducible factor-proline dioxygenase.
based on mapping to UniProt Q9GZT9
Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia- inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2).
-!- Contains iron, and requires ascorbate. -!- Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. -!- The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.
|
UniProtKB Entries (1)
| Q9GZT9 |
EGLN1_HUMAN
Homo sapiens
Egl nine homolog 1
|
PDB Structure
| PDB | 5OX5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Chem Sci
|