CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 5

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P54829
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P54829
PTN5_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 5

PDB Structure

PDB 5OVX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
Witten, M.R., Wissler, L., Snow, M., Geschwindner, S., Read, J.A., Brandon, N.J., Nairn, A.C., Lombroso, P.J., Kack, H., Ellman, J.A.
J. Med. Chem.