CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Casein kinase II subunit alpha

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P68400
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P68400
CSK21_HUMAN
Homo sapiens
Casein kinase II subunit alpha

PDB Structure

PDB 5OTZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Second-generation CK2 alpha inhibitors targeting the alpha D pocket.
Iegre, J., Brear, P., De Fusco, C., Yoshida, M., Mitchell, S.L., Rossmann, M., Carro, L., Sore, H.F., Hyvonen, M., Spring, D.R.
Chem Sci