CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.170 | Elastase; domain 1 |
|
3.10.170.10 |
Domain Context
CATH Clusters
| Superfamily | 3.10.170.10 |
| Functional Family |
Enzyme Information
| 3.4.24.27 |
Thermolysin.
based on mapping to UniProt P43133
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.
|
UniProtKB Entries (2)
| P43133 |
THER_GEOSE
Geobacillus stearothermophilus
Thermolysin
|
| P05067 |
A4_HUMAN
Homo sapiens
Amyloid-beta precursor protein
|
PDB Structure
| PDB | 5ONP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett.
|
