CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.53
3',5'-cyclic-AMP phosphodiesterase.
based on mapping to UniProt Q07343
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.

UniProtKB Entries (1)

Q07343
PDE4B_HUMAN
Homo sapiens
CAMP-specific 3',5'-cyclic phosphodiesterase 4B

PDB Structure

PDB 5OHJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases.
Carzaniga, L., Amari, G., Rizzi, A., Capaldi, C., De Fanti, R., Ghidini, E., Villetti, G., Carnini, C., Moretto, N., Facchinetti, F., Caruso, P., Marchini, G., Battipaglia, L., Patacchini, R., Cenacchi, V., Volta, R., Amadei, F., Pappani, A., Capacchi, S., Bagnacani, V., Delcanale, M., Puccini, P., Catinella, S., Civelli, M., Armani, E.
J. Med. Chem.