CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.160.20
Functional Family

Enzyme Information

1.3.1.91
tRNA-dihydrouridine(20) synthase (NAD(P)(+)).
based on mapping to UniProt Q9NX74
5,6-dihydrouracil(20) in tRNA + NAD(P)(+) = uracil(20) in tRNA + NAD(P)H.
-!- The enzyme specifically modifies uracil(20) in tRNA.

UniProtKB Entries (1)

Q9NX74
DUS2L_HUMAN
Homo sapiens
TRNA-dihydrouridine(20) synthase [NAD(P)+]-like

PDB Structure

PDB 5OC4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.
Bou-Nader, C., Barraud, P., Pecqueur, L., Perez, J., Velours, C., Shepard, W., Fontecave, M., Tisne, C., Hamdane, D.
Nucleic Acids Res.