CATH Domain 5n9sA02

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Dual specificity protein kinase TTK

2.7.12.1

Dual-specificity kinase.

based on mapping to UniProt P33981

ATP + a protein = ADP + a phosphoprotein.

-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

TTK_HUMAN

Homo sapiens

Dual specificity protein kinase TTK

PDB	5N9S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. Uitdehaag, J.C.M., de Man, J., Willemsen-Seegers, N., Prinsen, M.B.W., Libouban, M.A.A., Sterrenburg, J.G., de Wit, J.J.P., de Vetter, J.R.F., de Roos, J.A.D.M., Buijsman, R.C., Zaman, G.J.R. J. Mol. Biol.