CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.530 | Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 |
|
3.30.530.20 | START domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.530.20 |
| Functional Family |
Enzyme Information
| 4.2.1.78 |
(S)-norcoclaurine synthase.
based on mapping to UniProt Q67A25
Dopamine + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H(2)O.
-!- The reaction makes a 6-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates. -!- The product is the precursor of the benzylisoquinoline alkaloids in plants. -!- Will also catalyze the reaction of 4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline, but this alkaloid has not been found to occur in plants.
|
UniProtKB Entries (1)
| Q67A25 |
NCS_THLFG
Thalictrum flavum subsp. glaucum
S-norcoclaurine synthase
|
PDB Structure
| PDB | 5N8Q |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase.
Biochemistry
|