1 keywords

CATH Domain 5n7tB01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.50 3-Layer(bba) Sandwich
Topology 3.50.50 FAD/NAD(P)-binding domain
Homologous Superfamily 3.50.50.60 FAD/NAD(P)-binding domain

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Kynurenine 3-monooxygenase

Enzyme Information

1.14.13.9
Kynurenine 3-monooxygenase.
based on mapping to UniProt Q84HF5
L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + NADP(+) + H(2)O.
-!- Formerly EC 1.14.1.2 and EC 1.99.1.5.

UniProtKB Entries (1)

Q84HF5
KMO_PSEFL
Pseudomonas fluorescens
Kynurenine 3-monooxygenase

PDB Structure

PDB 5N7T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
Liddle, J., Beaufils, B., Binnie, M., Bouillot, A., Denis, A.A., Hann, M.M., Haslam, C.P., Holmes, D.S., Hutchinson, J.P., Kranz, M., McBride, A., Mirguet, O., Mole, D.J., Mowat, C.G., Pal, S., Rowland, P., Trottet, L., Uings, I.J., Walker, A.L., Webster, S.P.
Bioorg. Med. Chem. Lett.