CATH Classification

Domain Context

CATH Clusters

Superfamily FAD-linked oxidases, C-terminal domain
Functional Family

Enzyme Information

1.1.3.38
Vanillyl-alcohol oxidase.
based on mapping to UniProt P56216
Vanillyl alcohol + O(2) = vanillin + H(2)O(2).
-!- Converts a wide range of 4-hydroxybenzyl alcohols and 4-hydroxybenzylamines into the corresponding aldehydes. -!- The allyl group of 4-allylphenols is also converted into the -CH=CH-CH(2)OH group.

UniProtKB Entries (1)

P56216
VAOX_PENSI
Penicillium simplicissimum
Vanillyl-alcohol oxidase

PDB Structure

PDB 5MXU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl-alcohol oxidase.
Ewing, T.A., Nguyen, Q.T., Allan, R.C., Gygli, G., Romero, E., Binda, C., Fraaije, M.W., Mattevi, A., van Berkel, W.J.H.
J. Biol. Chem.