CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.50 | Coagulation Factor XIII; Chain A, domain 1 |
|
2.70.50.40 | GMP phosphodiesterase, delta subunit |
Domain Context
CATH Clusters
| Superfamily | GMP phosphodiesterase, delta subunit |
| Functional Family | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
Enzyme Information
UniProtKB Entries (1)
| O43924 |
PDE6D_HUMAN
Homo sapiens
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
|
PDB Structure
| PDB | 5ML2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A PDE6 delta-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.
Angew. Chem. Int. Ed. Engl.
|