CATH Classification

Domain Context

CATH Clusters

Superfamily Creatinase/methionine aminopeptidase superfamily
Functional Family

Enzyme Information

3.4.13.9
Xaa-Pro dipeptidase.
based on mapping to UniProt P12955
Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.
-!- Possibly thiol dependent. -!- Cytosolic from most animal tissues. -!- Belongs to peptidase family M24A. -!- Formerly EC 3.4.3.7.

UniProtKB Entries (1)

P12955
PEPD_HUMAN
Homo sapiens
Xaa-Pro dipeptidase

PDB Structure

PDB 5MC3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for prolidase deficiency disease mechanisms.
Wilk, P., Uehlein, M., Piwowarczyk, R., Dobbek, H., Mueller, U., Weiss, M.S.
FEBS J.