CATH Classification

Domain Context

CATH Clusters

Superfamily PCRA; domain 4
Functional Family RecBCD enzyme subunit RecB

Enzyme Information

3.1.11.5
Exodeoxyribonuclease V.
based on mapping to UniProt P08394
Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.
-!- Preference for double-stranded DNA. -!- Possesses DNA-dependent ATPase activity. -!- Acts endonucleolytically on single-stranded circular DNA. -!- Similar enzyme: Haemophilus influenzae ATP-dependent DNase.

UniProtKB Entries (2)

P07648
RECC_ECOLI
Escherichia coli K-12
RecBCD enzyme subunit RecC
P03702
GAM_LAMBD
Escherichia virus Lambda
Host-nuclease inhibitor protein gam

PDB Structure

PDB 5MBV
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones.
Wilkinson, M., Troman, L., Wan Nur Ismah, W.A., Chaban, Y., Avison, M.B., Dillingham, M.S., Wigley, D.B.
Elife