CATH Domain 5m5eD00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1250	Growth Hormone; Chain: A;
	1.20.1250.10

Domain Context

CATH Clusters

Superfamily	1.20.1250.10
Functional Family	Interleukin-2

Enzyme Information

UniProtKB Entries (1)

IL2RB_HUMAN

Homo sapiens

Interleukin-2 receptor subunit beta

PDB Structure

PDB	5M5E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines. Klein, C., Waldhauer, I., Nicolini, V.G., Freimoser-Grundschober, A., Nayak, T., Vugts, D.J., Dunn, C., Bolijn, M., Benz, J., Stihle, M., Lang, S., Roemmele, M., Hofer, T., van Puijenbroek, E., Wittig, D., Moser, S., Ast, O., Brunker, P., Gorr, I.H., Neumann, S., de Vera Mudry, M.C., Hinton, H., Crameri, F., Saro, J., Evers, S., Gerdes, C., Bacac, M., van Dongen, G., Moessner, E., Umana, P. Oncoimmunology