CATH Domain 5m5eC01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Cytokine receptor common subunit gamma

Enzyme Information

UniProtKB Entries (1)

IL2RB_HUMAN

Homo sapiens

Interleukin-2 receptor subunit beta

PDB Structure

PDB	5M5E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines. Klein, C., Waldhauer, I., Nicolini, V.G., Freimoser-Grundschober, A., Nayak, T., Vugts, D.J., Dunn, C., Bolijn, M., Benz, J., Stihle, M., Lang, S., Roemmele, M., Hofer, T., van Puijenbroek, E., Wittig, D., Moser, S., Ast, O., Brunker, P., Gorr, I.H., Neumann, S., de Vera Mudry, M.C., Hinton, H., Crameri, F., Saro, J., Evers, S., Gerdes, C., Bacac, M., van Dongen, G., Moessner, E., Umana, P. Oncoimmunology