CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase receptor

Enzyme Information
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q9UM73
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
ALK tyrosine kinase receptor

PDB Structure

External Links
Primary Citation
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.
Johnson, T.W., Richardson, P.F., Bailey, S., Brooun, A., Burke, B.J., Collins, M.R., Cui, J.J., Deal, J.G., Deng, Y.L., Dinh, D., Engstrom, L.D., He, M., Hoffman, J., Hoffman, R.L., Huang, Q., Kania, R.S., Kath, J.C., Lam, H., Lam, J.L., Le, P.T., Lingardo, L., Liu, W., McTigue, M., Palmer, C.L., Sach, N.W., Smeal, T., Smith, G.L., Stewart, A.E., Timofeevski, S., Zhu, H., Zhu, J., Zou, H.Y., Edwards, M.P.
J. Med. Chem.