CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.11350
Functional Family GDP-fucose protein O-fucosyltransferase 1

Enzyme Information

2.4.1.221
Peptide-O-fucosyltransferase.
based on mapping to UniProt Q91ZW2
Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.
-!- Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats. -!- The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.

UniProtKB Entries (1)

Q91ZW2
OFUT1_MOUSE
Mus musculus
GDP-fucose protein O-fucosyltransferase 1

PDB Structure

PDB 5KY0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.
Li, Z., Han, K., Pak, J.E., Satkunarajah, M., Zhou, D., Rini, J.M.
Nat. Chem. Biol.