CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt Q8DBF5
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

Q8DBF5
DXR_VIBVU
Vibrio vulnificus CMCP6
1-deoxy-D-xylulose 5-phosphate reductoisomerase

PDB Structure

PDB 5KRY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characterization of 1-deoxy-D-xylulose 5-phosphate Reductoisomerase from Vibrio vulnificus.
Ussin, N.K., Bagnell, A.M., Offermann, L.R., Abdulsalam, R., Perdue, M.L., Magee, P., Chruszcz, M.
Biochim Biophys Acta Proteins Proteom