CATH Classification

Domain Context

CATH Clusters

Superfamily Galactose-binding domain-like
Functional Family furin isoform X2

Enzyme Information

3.4.21.75
Furin.
based on mapping to UniProt P09958
Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
-!- Activated by calcium. -!- Belongs to peptidase family S8.

UniProtKB Entries (1)

P09958
FURIN_HUMAN
Homo sapiens
Furin

PDB Structure

PDB 5JXG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Dahms, S.O., Arciniega, M., Steinmetzer, T., Huber, R., Than, M.E.
Proc.Natl.Acad.Sci.USA