CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.260 | Galactose-binding domain-like |
Domain Context
CATH Clusters
| Superfamily | Galactose-binding domain-like |
| Functional Family | furin isoform X2 |
Enzyme Information
| 3.4.21.75 |
Furin.
based on mapping to UniProt P09958
Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
-!- Activated by calcium. -!- Belongs to peptidase family S8.
|
UniProtKB Entries (1)
| P09958 |
FURIN_HUMAN
Homo sapiens
Furin
|
PDB Structure
| PDB | 5JXG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA
|
