CATH Domain 5j5oA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.760	RNA Cap, Translation Initiation Factor Eif4e
	3.30.760.10	RNA Cap, Translation Initiation Factor Eif4e

Domain Context

CATH Clusters

Superfamily	RNA Cap, Translation Initiation Factor Eif4e
Functional Family	Eukaryotic translation initiation factor 4E

Enzyme Information

UniProtKB Entries (1)

IF4E_MOUSE

Mus musculus

Eukaryotic translation initiation factor 4E

PDB Structure

PDB	5J5O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Rydzik, A.M., Warminski, M., Sikorski, P.J., Baranowski, M.R., Walczak, S., Kowalska, J., Zuberek, J., Lukaszewicz, M., Nowak, E., W Claridge, T.D., Darzynkiewicz, E., Nowotny, M., Jemielity, J. Nucleic Acids Res.