CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family |
Enzyme Information
| 4.2.3.146 |
Cyclooctat-9-en-7-ol synthase.
based on mapping to UniProt C9K1X5
Geranylgeranyl diphosphate + H(2)O = cyclooctat-9-en-7-ol + diphosphate.
-!- Isolated from the bacterium Streptomyces melanosporofaciens, where it is part of the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase.
|
UniProtKB Entries (1)
| C9K1X5 |
COTB2_STRMJ
Streptomyces melanosporofaciens
Cyclooctat-9-en-7-ol synthase
|
PDB Structure
| PDB | 5GUE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol
ACS Chem. Biol.
|
