CATH Domain 5fntA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.80	Kelch-type beta propeller

Domain Context

CATH Clusters

Superfamily	Kelch-type beta propeller
Functional Family	Kelch-like ECH-associated protein 1

Enzyme Information

UniProtKB Entries (1)

KEAP1_MOUSE

Mus musculus

Kelch-like ECH-associated protein 1

PDB Structure

PDB	5FNT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., Mcmenamin, R.L., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G.A., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K. J.Med.Chem.