CATH Classification

Domain Context

CATH Clusters

Superfamily Adenoviral Proteinase; Chain A
Functional Family Protease

Enzyme Information

3.4.22.39
Adenain.
based on mapping to UniProt P03252
Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-|-Xaa- and -Yaa-Xaa-Gly-Xaa-|-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid).
-!- A cysteine endopeptidase from adenoviruses. -!- Activity is greatly stimulated by the binding to the enzyme of an 11-residue peptide from the adenovirus capsid protein pre-VI at a site separate from the active site. -!- Belongs to peptidase family C5.

UniProtKB Entries (1)

P03252
PRO_ADE02
Human adenovirus 2
Protease

PDB Structure

PDB 5FGY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of human adenovirus 2 protease with cofactor pVIC
Davis, R.R., Martinez, P., Hollis, T.
To Be Published