CATH Classification

Domain Context

CATH Clusters

Superfamily Isopropylmalate Dehydrogenase
Functional Family Isocitrate dehydrogenase [NADP]

Enzyme Information

1.1.1.42
Isocitrate dehydrogenase (NADP(+)).
based on mapping to UniProt O75874
Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
-!- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NAD(+) but much more slowly.

UniProtKB Entries (1)

O75874
IDHC_HUMAN
Homo sapiens
Isocitrate dehydrogenase [NADP] cytoplasmic

PDB Structure

PDB 5DE1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.
Okoye-Okafor, U.C., Bartholdy, B., Cartier, J., Gao, E.N., Pietrak, B., Rendina, A.R., Rominger, C., Quinn, C., Smallwood, A., Wiggall, K.J., Reif, A.J., Schmidt, S.J., Qi, H., Zhao, H., Joberty, G., Faelth-Savitski, M., Bantscheff, M., Drewes, G., Duraiswami, C., Brady, P., Groy, A., Narayanagari, S.R., Antony-Debre, I., Mitchell, K., Wang, H.R., Kao, Y.R., Christopeit, M., Carvajal, L., Barreyro, L., Paietta, E., Makishima, H., Will, B., Concha, N., Adams, N.D., Schwartz, B., McCabe, M.T., Maciejewski, J., Verma, A., Steidl, U.
Nat.Chem.Biol.