CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Sulfate adenylyltransferase

Enzyme Information

2.7.1.25
Adenylyl-sulfate kinase.
based on mapping to UniProt P72940
ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.
-!- The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP. -!- This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25.

UniProtKB Entries (1)

P72940
CYSC_SYNY3
Synechocystis sp. PCC 6803 substr. Kazusa
Probable adenylyl-sulfate kinase

PDB Structure

PDB 5CB6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Recapitulating the Structural Evolution of Redox Regulation in Adenosine 5'-Phosphosulfate Kinase from Cyanobacteria to Plants.
Herrmann, J., Nathin, D., Lee, S.G., Sun, T., Jez, J.M.
J.Biol.Chem.