CATH Domain 5by6D00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Possible thymidylate synthase

Enzyme Information

UniProtKB Entries (1)

Q9NDD3_TRISP

Trichinella spiralis

Thymidylate synthase

PDB Structure

PDB	5BY6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS. Jarmula, A., Wilk, P., Maj, P., Ludwiczak, J., Dowiercial, A., Banaszak, K., Rypniewski, W., Ciesla, J., Dabrowska, M., Fraczyk, T., Bronowska, A.K., Jakowiecki, J., Filipek, S., Rode, W. J. Mol. Graph. Model.