CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.670
Functional Family DNA gyrase subunit B

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P9WG44
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (2)

P9WG47
GYRA_MYCTU
Mycobacterium tuberculosis H37Rv
DNA gyrase subunit A
P9WG44
GYRB_MYCTO
Mycobacterium tuberculosis CDC1551
DNA gyrase subunit B

PDB Structure

PDB 5BTL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Blower, T.R., Williamson, B.H., Kerns, R.J., Berger, J.M.
Proc.Natl.Acad.Sci.USA