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1 keywords

CATH Domain 5ajpA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.550 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homologous Superfamily 3.90.550.10 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family Polypeptide N-acetylgalactosaminyltransferase

Enzyme Information

2.4.1.41
Polypeptide N-acetylgalactosaminyltransferase.
based on mapping to UniProt Q10471
(1) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine. (2) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine.
-!- The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.

UniProtKB Entries (1)

P98088
MUC5A_HUMAN
Homo sapiens
Mucin-5AC

PDB Structure

PDB 5AJP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dynamic Interplay between Catalytic and Lectin Domains of Galnac-Transferases Modulates Protein O-Glycosylation.
Lira-Navarrete, E., De Las Rivas, M., Companon, I., Pallares, M.C., Kong, Y., Iglesias-Fernandez, J., Bernardes, G.J.L., Peregrina, J.M., Rovira, C., Bernado, P., Bruscolini, P., Clausen, H., Lostao, A., Corzana, F., Hurtado-Guerrero, R.
Nat.Commun.
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