CATH Classification

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family ATPase family AAA domain-containing protein 2

Enzyme Information

3.6.1.3
Adenosinetriphosphatase.
based on mapping to UniProt Q6PL18
ATP + H(2)O = ADP + phosphate.
-!- Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39. -!- The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA. -!- Formerly EC 3.6.1.4.

UniProtKB Entries (1)

Q6PL18
ATAD2_HUMAN
Homo sapiens
ATPase family AAA domain-containing protein 2

PDB Structure

PDB 5A83
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors.
Bamborough, P., Chung, C., Furze, R.C., Grandi, P., Michon, A., Sheppard, R.J., Barnett, H., Diallo, H., Dixon, D.P., Douault, C., Jones, E.J., Karamshi, B., Mitchell, D.J., Prinjha, R.K., Rau, C., Watson, R.J., Werner, T., Demont, E.H.
J.Med.Chem.