CATH Domain 5a5wA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Enzyme Information

5.3.1.16

1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase.

based on mapping to UniProt P10372

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D- ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1- deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide.

-!- Involved in histidine biosynthesis.

UniProtKB Entries (1)

P10372

HIS4_SALTY

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

PDB Structure

PDB	5A5W
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa Soderholm, A., Guo, X., Newton, M.S., Evans, G.B., Nasvall, J., Patrick, W.M., Selmer, M. J.Biol.Chem.