CATH Classification

Domain Context

CATH Clusters

Superfamily Glucose Permease (Domain IIA)
Functional Family

Enzyme Information

3.4.24.75
Lysostaphin.
based on mapping to UniProt O33599
Hydrolysis of the -Gly-|-Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans.
-!- Lyses cells of Staphylococcus aureus in particular, by its action on the cross-bridge of the cell wall. -!- Belongs to peptidase family M23.

UniProtKB Entries (1)

O33599
LYTM_STAA8
Staphylococcus aureus subsp. aureus NCTC 8325
Glycyl-glycine endopeptidase LytM

PDB Structure

PDB 4ZYB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High resolution structure of an M23 peptidase with a substrate analogue.
Grabowska, M., Jagielska, E., Czapinska, H., Bochtler, M., Sabala, I.
Sci Rep