CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.170 | Beta Complex |
|
2.170.120 | RNA Polymerase Alpha Subunit; Chain A, domain 2 |
|
2.170.120.12 | DNA-directed RNA polymerase, insert domain |
Domain Context
CATH Clusters
| Superfamily | DNA-directed RNA polymerase, insert domain |
| Functional Family | DNA-directed RNA polymerase subunit alpha |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt A7ZSI4
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (3)
| A7ZUK2 |
RPOC_ECO24
Escherichia coli O139:H28 str. E24377A
DNA-directed RNA polymerase subunit beta'
|
| B1IYV1 |
RPOZ_ECOLC
Escherichia coli ATCC 8739
DNA-directed RNA polymerase subunit omega
|
| P00579 |
RPOD_ECOLI
Escherichia coli K-12
RNA polymerase sigma factor RpoD
|
PDB Structure
| PDB | 4XSZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA
|
